Cellarity publishes groundbreaking framework for predicting drug safety in Nature Communications
Peer-Reviewed Publication
Updates every hour. Last Updated: 26-Dec-2025 13:11 ET (26-Dec-2025 18:11 GMT/UTC)
An elevated blood glucose level one hour after the oral glucose tolerance test (OGTT) signals a critical metabolic state – even before prediabetes. Affected individuals respond particularly well to lifestyle interventions. This value could become a new clinically relevant biomarker – and enable more targeted, earlier prevention of type 2 diabetes. This is the conclusion reached by a team from the University of Tübingen, Helmholtz Munich and the German Center for Diabetes Research (DZD). This research, conducted in cooperation with Prof. Michael Bergman from New York University, has now been published in Metabolism.
The time of eating influences the lipid metabolism in our body. A study conducted at the German Center for Diabetes Research (DZD) and the German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE) shows: Eating earlier in the day leads to measurable changes in fat metabolism, as compared to a later eating window with the same calorie intake and nutrient composition.The time of eating influences the lipid metabolism in our body. A study conducted at the German Center for Diabetes Research (DZD) and the German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE) shows: Eating earlier in the day leads to measurable changes in fat metabolism, as compared to a later eating window with the same calorie intake and nutrient composition.
The aberrant overexpression of Lysine-specific demethylase 1 (LSD1/KDM1A) is a common feature across a wide spectrum of human cancers, and its elevated levels correlate with poor survival of cancer patients, making it an attractive target for pharmacological intervention. However, the clinical trials of LSD1 small-molecule inhibitors are facing few serious challenges, including toxicity at therapeutic doses. Here, the authors reported the discovery of LD-110 as a potent PROTAC degrader via the ubiquitin-proteasome system, leading to significantly growth suppression of cancer cells both in vitro and in vivo.
Gout, a curable arthritis, now aims for long-term remission over flare control. Professors Towiwat and Li's review in the journal Rheumatology & Autoimmunity synthesizes evidence to define remission, identifies key challenges, and outlines comprehensive management strategies. This work provides clinicians with clear, practical guidance for achieving sustained disease control.
The Synapsy Centre for Neuroscience Research in Mental at the University of Geneva (UNIGE) Faculty of Medicine has awarded its first prize to Professor Eric Nestler, a leading figure in the neurobiology of depression and addiction. The prize recognises a career dedicated to linking fundamental discoveries about the brain to concrete clinical advances in mental health.