G9a-mediated H3K9me2 protects centromere integrity
Peer-Reviewed Publication
Updates every hour. Last Updated: 10-Oct-2025 06:11 ET (10-Oct-2025 10:11 GMT/UTC)
The centromere is a unique chromosomal locus responsible for the faithful segregation of chromosomes during cell division. Disruption of centromere integrity frequently causes aberrant chromosome segregation and chromosome instability, a hallmark of cancers. The function of G9a/GLP-mediated H3K9me2 at (peri)centromeric heterochromatin remains elusive. A study published in Science Bulletin carefully investigated this topic and revealed an important role of H3K9me2 in protecting the centromeric chromatin landscape and thus ensuring accurate chromosome segregation.
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