The interplay between the circadian clock, intestinal stem cell niche, and epithelial cell fate is shaping our understanding of how gut homeostasis and cellular regeneration are regulated. Recent insights reveal that the circadian rhythm, a fundamental 24-hour cycle regulating numerous physiological functions, plays a crucial role in maintaining intestinal health by coordinating the proliferation and differentiation of intestinal epithelial cells.

A network analysis of more than 26,000 dogs and their health conditions helps reveal which diseases tend to go together, providing data that veterinarians and researchers can use to help treat the problems that dog man’s best friend face, according to a study published DATE in the open-access journal PLOS Computational Biology by Antoinette Fang from the Fred Hutchingson Cancer Center in Seattle, Washington, USA, and colleagues.