This study evaluates the clinical efficacy and safety of modified deep lateral wall decompression surgery in thyroid-associated ophthalmopathy and optic neuropathy, demonstrating significant postoperative improvements in vision, exophthalmos, and intraocular pressure with a low rate of complications.

A new fluorescent reporter capable of visualizing biologically active iron and oxygen inside living cells at single-cell resolution has been developed, as reported by researchers from Science Tokyo. Using this new tool, they revealed striking differences in the distribution of iron and oxygen across organs and even between neighboring cells of the same type. This innovation could serve as a platform for studying cancer, liver diseases, neurodegeneration, and aging.

NATO battlefield surgery and trauma training courses, as well as practical and simulation-based programs, were among the first activities hosted by Semmelweis University’s newly established Anatomy & Innovation Center for Education and Research (AICER). Opened in April, the facility provides physicians and healthcare professionals with realistic environments for learning and practicing new surgical and diagnostic procedures before introducing them into patient care. The center aims to improve patient safety and quality of care through advanced technologies and hands-on training.

A new article published in Globalization and Health warns that the rapid rise of GLP-1 weight-loss drugs in high-income countries could have unintended consequences for food environments in low- and middle-income countries.

New culture system enables the stable, scalable, and low-cost production of clinical-grade intestinal organoids, as reported by researchers from Science Tokyo. Whereas conventional organoid cultures rely on materials and substances unsuitable for clinical use, this innovative strategy uses clinical-grade collagen and good manufacturing practice-compliant reagents/factors and techniques to achieve drastically enhanced growth. The results put us one step closer to organoid-based regenerative therapies for conditions like inflammatory bowel disease.

Serious mental illnesses have long been sorted into separate diagnostic boxes, yet they cluster stubbornly within the same families. Researchers examined 173 multiplex families from the Portuguese Island Collection, drawn from the genetically isolated Azores and Madeira. In 28 percent of those families, psychosis and mood disorders co-segregated; in 7 percent, autism and intellectual disability joined the same pedigree. Whole-genome sequencing of one three-generation family uncovered an ultra-rare loss-of-function mutation in CHD2 that appeared as schizophrenia in most carriers and as autism in another. The work argues that founder-population families can expose rare, large-effect variants spanning the diagnostic spectrum.