Researchers from Amsterdam UMC, in collaboration with other hospitals, have successfully completed the first-ever Phase 3 study of an in vivo CRISPR therapy. In this large-scale, double-blind Phase 3 trial, 80 patients with hereditary angioedema were randomized to receive either the CRISPR therapy or a placebo. CRISPR therapy is a medical technique that allows doctors to precisely modify errors in cellular DNA to treat specific hereditary diseases. Danny Cohn, leader of the research, is highly enthusiastic: "The study demonstrates that the therapy is genuinely effective and safe. This confirmation is exactly what regulatory authorities need to approve the very first in vivo CRISPR gene editing treatment for the market."

As more than 40% of American teenagers report persistent feelings of sadness or hopelessness, a leading child psychologist says grandparents and extended family have a vital role to play.

Researchers have developed a new way of testing for foetal abnormalities using a simple blood draw from the mother that is able to identify a very high proportion of the clinically relevant genetic variants that are currently only detectable by invasive testing.

Women with HIV most often die from preventable, trauma-related conditions like substance use and mental illness — not the virus itself. Yet, these leading causes are largely missing from official death records, according to new research by UC San Francisco.

Recent Hantavirus cases, including the MV Hondius cruise outbreak, show renewed global concern. Agricultural and wildlife-farming  environment remain overlooked hotspots for rodent-borne Hantavirus exposure. One Health prevention is needed through rodent control, PPE, farm hygiene, and surveillance.

A molecular geneticist at Montana State University has discovered a cellular process once believed impossible by scientists – the creation of the amino acid cysteine within a living cell when the cell’s primary systems to do so fail. The discovery may one day lead to new cancer treatments.