In a groundbreaking study led by Dr. Ying Chen and her team from Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, researchers have uncovered a novel mechanism behind endothelial dysfunction in sepsis-induced acute respiratory distress syndrome (ARDS). This study, which has significant implications for the treatment of sepsis and its complications, demonstrates how glycolysis-induced histone lactylation drives endothelial cell (EC) activation and promotes lung injury in sepsis.

Female sexual dysfunction (FSD), a condition affecting women's sexual arousal, desire, orgasm, or pain, has been identified as a hidden epidemic in China with a higher incidence in rural areas compared to urban ones. A four-year prospective cohort study provides a detailed analysis of FSD's incidence and associated risk factors, shedding light on the need for targeted public health strategies. The research involved a nationally representative sample of women from six provinces in China, capturing a diverse range of geographic and socioeconomic regions. The study utilized the Female Sexual Function Index (FSFI), a widely recognized tool for evaluating sexual dysfunction, to assess participants at baseline and during the follow-up period.

People with pockets of fat hidden inside their muscles are at a higher risk of dying or being hospitalised from a heart attack or heart failure, regardless of their body mass index, according to research published in the European Heart Journal. This ‘intermuscular’ fat is highly prized in beef steaks for cooking. However, little is known about this type of body fat in humans, and its impact on health. This is the first study to comprehensively investigate the effects of fatty muscles on heart disease. The new finding adds evidence that existing measures, such as body mass index or waist circumference, are not adequate to evaluate the risk of heart disease accurately for all people.