A proof-of-concept study suggests a monoclonal antibody could offer much-needed treatment for ARDS.

This peer-reviewed invited review recasts traumatic brain injury not as a single bruise to the head but as a system-wide disorder that ripples through the lungs, heart, kidneys, and gut. Synthesizing evidence from rodents, swine, and nonhuman primates through early human case reports, the authors examine mesenchymal stromal cell-derived extracellular vesicles, the tiny membrane-bound parcels cells shed to talk to one another. The synthesis reveals that these vesicles can quiet inflammation, blunt cell death, and coax new vessels and neurons. The authors map cargo engineering, delivery routes, and artificial intelligence-guided design while flagging the standardization gaps that still separate promise from practice.

This Brain Medicine mini-review gathers a decade of converging research on plasma neurofilament light chain (NfL), a protein shed from injured neurons that has become a leading blood-based window onto neuronal damage in Alzheimer’s disease. Synthesizing existing studies rather than reporting new experiments, the authors trace how rising NfL tracks cognitive decline, brain atrophy, and disease progression. Their central argument concerns biological sex. The analysis concludes that an identical NfL level may reflect a more advanced process in men than in women, making sex-specific interpretation a clinical necessity rather than a refinement.

Stress does its damage quietly, and somatostatin may be one of the quietest places it lands. This peer-reviewed Thought Leaders Invited Review gathers fifty years of molecular, circuit, and clinical work to ask how a single inhibitory peptide, and the neurons that carry it, govern the way the brain meets a threat. A consistent shape emerges from the synthesis. Stress reshapes somatostatin signaling across the amygdala, prefrontal cortex, zona incerta, and hippocampus, and the same disruption surfaces in depression, anxiety, and several neurodegenerative diseases. The authors argue these circuits could yield gentler antidepressants, while naming honestly what

Why do nearly all animals sleep? A new Perspective in Brain Medicine gathers evidence from neuroimaging, electrophysiology, and machine learning to propose an answer that sits above the familiar ones. The authors synthesize existing research to argue that sleep operates as a system-level resilience mechanism, stabilizing large-scale brain dynamics, curbing maladaptive over-specialization, and preserving efficient information flow. NREM and REM stages emerge as coordinated phases of repair and reconfiguration. The same logic, the authors suggest, may extend to artificial neural networks, where structured offline phases could ease catastrophic forgetting. Sleep, in this reading, is active maintenance rather than passive rest.

The Medical College of Wisconsin is leading a new multi-center clinical trial to evaluate an interdisciplinary rehabilitation model for military veterans and first responders with mild traumatic brain injury and co-occurring disorders such as depression, anxiety, and post-traumatic stress disorder. Sponsored by Avalon Action Alliance, the Veteran’s Interdisciplinary Care for TBI and co-Occurring disorders Rehabilitation Trial (VICTORY-RCT) is one of the most rigorous rehabilitation studies of its kind to date.