Not all lung cancers with the same common genetic driver respond equally to powerful targeted drugs. Researchers have now discovered why: subtle differences in the 3D shape of the mutated protein. By classifying these shapes, they identified a subtype that poorly binds to latest-generation drugs, explaining worse outcomes. The good news? Starting with a drug-chemo combo likely overcomes this resistance, offering a clear path to personalize first-line treatment.

A study of more than 800 teens finds that lower dopamine early in adolescence is linked to greater substance experimentation, which often declines as the brain matures and dopamine increases, challenging long‑held assumptions about teen risk‑taking.

UC San Diego researchers have identified genetic drivers of cocaine addiction, uncovering a potential new treatment target in the liver. This large-scale study maps how metabolism influences addiction-like behavior to bridge the gap to human medicine.

This study explores the bidirectional skin–brain axis in 305 Brazilian adults, revealing strong correlations between anxiety, depression, and stress. Women exhibited significantly higher psychological symptom scores than men. Although dermatology-related quality of life showed weak correlations with mental health, nearly half of participants reported skin disorders and over half were at risk for a mental health condition. Probiotic intake showed no significant association with mental health outcomes, likely due to low consumption levels. Stress and depression independently predicted anxiety. The findings underscore the greater psychological burden on women and highlight the need for longitudinal, culturally tailored research on gut–skin–brain interactions.

Periprosthetic joint infection (PJI) is a devastating complication of joint replacement surgery. A new study in the Journal of Sport and Health Science discovers that musclin, a hormone released by muscles during exercise, directly binds to macrophages. This interaction rewires cellular metabolism, significantly boosting the macrophages' ability to clear dead cells (efferocytosis). This process effectively resolves inflammation, reduces bacterial burden, and promotes tissue repair, offering a promising "exercise-mimetic" therapeutic strategy for managing implant-associated infections.