Deoxyhypusine synthase (DHPS) is a human enzyme required for the replication of a broad range of viruses. Researchers at Korea University have developed an artificial intelligence (AI)-based pipeline for designing DHPS inhibitors. All three compounds predicted to be active showed inhibition in laboratory assays, with two demonstrating measurable potency. The findings demonstrate the feasibility of an AI-guided, host-directed approach to antiviral drug discovery.

A Johns Hopkins Medicine-led research team has received an award of up to $52.1 million over four years from the Advanced Research Projects Agency for Health (ARPA-H), part of the Department of Health and Human Services, to better understand the rules that decide what shape a protein takes — and how those rules could support the identification of earlier diagnostics and therapeutic targets when proteins fold the wrong way. The team will start this work, which will be publicly shared through open-access resources, by studying Parkinson’s disease and Ewing sarcoma, a rare cancer of bone and soft tissue in children and young adults.

Improving X-ray imaging under photon-starved conditions could enable lower-dose and higher-resolution imaging for medical diagnosis, security inspection, and industrial testing. Researchers from Chongqing University, the 26th Institute of CETC, and Stevens Institute of Technology developed a scalable photonic crystal scintillator using Marangoni effect-driven interfacial self-assembly. The approach increased average light output by 4.64-fold and improved the X-ray imaging signal-to-noise ratio by 13 dB while maintaining spatial resolution better than 25 μm.

Artificial intelligence has already demonstrated great promise in many aspects of biomedical research, from accelerating scientific discovery to speeding the translation of biological insights into new therapies. Scripps Research today announced it has received a significant award of in-kind compute power from the Jen-Hsun and Lori Huang Foundation to advance the adoption of AI into biomedicine and help realize its potential. The grant, totaling more than 14 million hours of compute time, is provided through the Huang Foundation's partnership with CoreWeave using NVIDIA GPUs.

In the International Journal of Extreme Manufacturing, researchers have resolved the trade-off between cell-friendly dilute bioinks and stable light-based printing by briefly chilling the ink into a temporary solid before light exposure.

Training doctors in rural and remote communities and embedding First Nations knowledge and leadership in medical education could be key to improving healthcare access and workforce sustainability in Australia, the United States and other underserved communities worldwide.

A new review in Infectious Diseases & Immunity brings together the evidence on how hantavirus infection affects the mouth and saliva. A severe sore throat lasting 2 to 3 weeks can be an early sign; very low platelet counts raise the risk of oral bleeding, and saliva shows promise as a non-invasive testing sample. For Andes virus, the only hantavirus known to spread between people, infectious virus has been recovered from saliva and gum fluid, so dental teams in endemic regions, and those seeing returning travelers, should know the signs and take sensible precautions.

Four in five parents say it costs too much to have a baby, according to the University of Michigan Health C.S. Mott Children’s Hospital National Poll on Children’s Health.