Collagenase-like protease (Clp) enhances the toxic effect of Streptococcus suis serotype 2 (SS2). Clp increases the permeability of the blood–brain barrier by disrupting tight junctions and inducing apoptosis of brain endothelial cells. Clp triggers brain endothelial cell apoptosis through cell receptor ligand apoptosis and mitochondrial apoptosis pathways, partially dependent on its enzyme activity.

Canada should rethink its reduced pledge to the Global Fund to protect the health of people in Canada as well as around the globe, argue authors in an editorial published in CMAJ (Canadian Medical Association Journal) https://www.cmaj.ca/lookup/doi/10.1503/cmaj.252036.

New research shows that 1 in 4 children with major traumatic injury do not receive care in a pediatric trauma centre, where outcomes are generally better than in adult centres. The authors of the study, published in CMAJ (Canadian Medical Association Journal) https://www.cmaj.ca/lookup/doi/10.1503/cmaj.250625, recommend evidence-based strategies to improve care for this vulnerable age group.

Researchers at University of Tsukuba have developed the Japanese version of the community-based rehabilitation indicators (CBR-Is), originally created by the World Health Organization to assess inclusive social participation among persons with disabilities. After a rigorous process of translation and cultural adaptation, the team confirmed that these indicators are suitable for use in the Japanese context.

Researchers at University of Tsukuba have comprehensively analyzed genomic binding data of transcription factors (proteins that regulate gene expression) in humans, revealing a substantial amount of unmeasured data. Their findings emphasize the urgent need for strategic prioritization in future data collection efforts to overcome research biases and deepen our understanding of disease mechanisms. To support the global research community, the results are now publicly available as an open-access database.