Korea University study identifies age 70 as cutoff for chemotherapy benefit in colorectal cancer
Peer-Reviewed Publication
Updates every hour. Last Updated: 21-Dec-2025 10:11 ET (21-Dec-2025 15:11 GMT/UTC)
Colorectal cancer is one of the most common and deadly cancers worldwide, and treatment decisions for older patients remain highly debated. Now, researchers have found that oxaliplatin-based chemotherapy significantly improves survival only in stage III colorectal cancer patients aged 70 or younger. For patients over 70, the drug offered no survival advantage and led to higher rates of treatment discontinuation due to toxicity. Importantly, stage II patients showed no survival benefit at any age.
This study deciphers the characteristics of human spinal cord neural stem cells (hscNSCs) specific to cervical, thoracic, and lumbar segments, and establishes an efficient method for amplifying hscNSCs from different spinal segments. A key finding: when transplanted into rat models with thoracic spinal cord injury (SCI), thoracic hscNSCs show superior therapeutic effects compared to cervical or lumbar hscNSCs. The research clarifies the critical role of segment-specific hscNSCs in spinal cord injury repair, offering valuable insights for targeted SCI treatment strategies.
Alzheimer’s disease is the leading cause of dementia, yet its underlying mechanisms remain unclear. A new review published in the Chinese Medical Journal highlights how immune cells, including T and B cells, contribute to brain inflammation in Alzheimer’s. By pulling together findings from recent decades, the study suggests that targeting these immune responses could open the door to better treatments and diagnosis, offering hope against one of the most devastating neurological disorders worldwide.
Social media use has long been part of the everyday lives of most children and adolescents. Many of them exhibit risky, and in some cases even addictive, behaviour. While social media use can certainly have positive effects for young people, intensive use can negatively impact mental, emotional, and social well-being, leading to symptoms such as depression and anxiety, impaired attention, and sleep problems. In a discussion paper published by the German National Academy of Sciences Leopoldina, the researchers involved therefore recommend applying the precautionary principle. In the paper “Social Media and the Mental Health of Children and Adolescents”, they give policy recommendations to protect children and adolescents from the negative effects of social media, for example by setting a minimum age for access or by restricting certain functions. The paper was published on 13 August 2025 and an English translation is now available.