Colder temperatures are linked with increased risk of diarrhea among Rohingya refugees in Bangladesh, emphasizing the need for climate-sensitive health strategies in refugee settings.

Cambridge, MA, April 18— Insilico Medicine(“Insilico”), a clinical-stage generative artificial intelligence (AI)-driven drug discovery company, is proud to announce  Pharma.AI Day 2025, the brand-new quarterly update series for Pharma.AI, scheduled on April 24, 10:00-11:00 AM EST. Register here to join Alex Zhavoronkov PhD, Founder and CEO of Insilico Medicine, and get a deep dive into a series of AI breakthroughs and new product demos.

Emotional stress, a common form of tension in daily life, can disrupt the body’s homeostasis. Beyond affecting peripheral organ functionality, maladaptive and uncontrollable responses to emotional stress may contribute to central nervous system disorders such as anxiety, post-traumatic stress disorder (PTSD), epilepsy, and ischemic stroke. Multiple brain regions in mammals are involved in coping with emotional stress, including the prefrontal cortex (PFC), amygdala, anterior insula, hippocampus, and striatum. Human neuroimaging evidence suggests that the medial prefrontal cortex (mPFC) is a critical locus within the adaptive behavioral coping circuit, regulating anxious emotions. Under emotional stress, the activation of the stress, immune, and oxidative systems can converge into a state of mutual activation, potentially leading to behavioral and biochemical changes, thus forming a vicious cycle.