Bone fractures heal more slowly with age, increasing health risks for older adults. A new study reveals that rising levels of the liver-produced protein apolipoprotein E (ApoE) interfere with bone repair by suppressing osteoblast activity. Using aged mouse models and human cells, scientists showed that neutralizing circulating ApoE restores bone formation and accelerates fracture healing. The findings highlight a promising noninvasive therapeutic strategy to improve bone healing in the elderly.

Scientists developed most advanced, functional human spinal cord organoid yet. The team induced lacerations and contusions to simulate spinal cord injuries. Then they applied “dancing molecules,” a new regenerative therapy that previously showed promise in animal models. "This is validation that our therapy has a good chance of working in humans," researcher says.

A new global study finds that physical inactivity is a major, preventable driver of serious diabetes complications worldwide. Analyzing data from more than 2.3 million adults with diabetes, researchers estimate that up to 10% of strokes, diabetic retinopathy, and heart failure cases could be avoided if recommended physical activity levels were met. The burden was disproportionately higher among women, people with lower educational attainment, and in several high- and middle-income regions.

A new study found that overweight and obese dogs have significantly higher eye pressure than lean dogs, with pressure increasing by 1.9 mmHg for every one-unit rise in body condition score. The research suggests that excess body fat and related metabolic changes may interfere with fluid drainage in the eye, potentially serving as a modifiable risk factor for dogs predisposed to glaucoma. These findings emphasize that maintaining a healthy weight is a vital part of protecting a dog's long-term vision and ocular health.