Distinguished psychiatrist John M. Oldham, MD, MS, discusses his pivotal role in developing the Alternative DSM-5 Model for Personality Disorders and creating assessment tools that bridge clinical practice with scientific rigor. His landmark work spans leadership positions at Columbia, Cornell, and Baylor, including serving as Chief Medical Officer for the New York State Office of Mental Health during 9/11.

IRCCS San Raffaele researcher Sara Poletti, PhD, demonstrates how childhood trauma fundamentally alters brain-immune interactions throughout life, contributing to mood disorders including depression and bipolar disorder. Her pioneering work combines neuroimaging, genetic analysis, and immunological assessments to map trauma's enduring neurobiological fingerprint, offering new therapeutic targets for psychiatric treatment.