Even a local mRNA injection can produce unwanted expression in the liver. Researchers have redesigned the lipid nanoparticles that carry mRNA to reduce this spillover in mice while preserving expression in injected muscle. The formulation also supports repeated dosing and improves the confinement of expression after local brain and eye delivery.

Umbilical cord blood is more than a source of stem cells for transplantation. A review in Science China Life Sciences examines how its diverse cells and bioactive components are being explored for cancer immunotherapy, inherited disorders and tissue repair. The authors connect these opportunities with advances in cell expansion, gene engineering and manufacturing, while identifying barriers to clinical translation. They emphasize that many emerging applications still require further evidence of safety, effectiveness and durable benefit.

A team led by the University of Exeter and City St George’s, University of London, discovered that the fungus creates multiple versions of its entire genome, including mutating a gene which plays a role in cell wall integrity, called “Crazy-one” (CRZ1).

Neutrophil RAGE drives cerebral vasospasm and impaired cortical circulation after subarachnoid hemorrhage, revealing a new therapeutic target.

A nationwide ChinaHEART cohort of 4,258,033 adults found that no single obesity measure provided consistently strong discrimination across all major chronic diseases. Relatively higher discrimination was observed for the Chinese visceral adiposity index (CVAI) in cardiovascular disease, the triglyceride-glucose index (TyG) in diabetes, and the a body shape index (ABSI) in COPD, while discrimination for cancer was generally limited. All measures showed limited discrimination for cancer, supporting disease- and population-specific risk assessment beyond BMI.

The LKS Faculty of Medicine of the University of Hong Kong (HKUMed) officially received the baton to host the World Health Summit (WHS) Regional Meeting 2027, Hong Kong, China, at the WHS Opening Night in Berlin, Germany, on 11 October 2026. The handover from Nairobi, the 2026 Regional Meeting host, set the stage for Hong Kong, China, to host this leading international platform for global health dialogue for the first time.