Our blood consists of many cell types that develop through different stages from a precursor type – the blood stem cell. An international research team led by Universitätsmedizin Frankfurt and Goethe University has now investigated the developmental pathways of blood cells in humans. The results yielded a surprise: Even stem cells possess surface proteins that enable them to suppress the activation of inflammatory and immune responses in the body. This finding is particularly relevant for stem cell transplants, applied for the treatment of e.g. leukemia.

A study from Hiroshima University found that when people were told to imagine their virtual bodies in pain, their brains resisted the illusion of ownership. Their findings could provide insights into why some people may struggle with feeling connected to their own bodies, particularly in contexts involving depersonalization or negative physical states.

Amit Bar-Or, MD, a distinguished researcher and neurologist at Penn Medicine, is the winner of the 2025 John Dystel Prize for Multiple Sclerosis Research.

Researchers at the Advanced Research Unit on Metabolism, Development & Aging (ARUMDA), in the Tata Institute of Fundamental Research (TIFR, Mumbai and TIFR Hyderabad), have unveiled a comprehensive understanding of the harmful effects of sugar-sweetened beverages (SSBs) on human health, using a preclinical mouse model that closely mimics human consumption patterns. The study, published in the Journal of Nutritional Biochemistry, sheds light on how chronic sucrose-water intake (10%) alters key physiological, molecular, and metabolic processes across various organs, driving the onset of diseases such as diabetes and obesity.

A research paper just published in Science China Life Sciences reports a gastric-adaptive hydrogen polysulfide microreactor (GAPSR), which can release a large amount of hydrogen polysulfide (H₂S_n, n≥2) and inactivate H. pylori glucose-6-phosphate dehydrogenase (G6PDH) by interfering with electron transfer from glucose-6-phosphate (G6P) to nicotinamide adenine dinucleotide phosphate (NADP⁺). This discovery provides a new scheme for the treatment of Helicobacter pylori infection.

This comprehensive review analyzes cutting-edge tools and technologies in modern pharmaceutical research, focusing on artificial intelligence, multi-omics technologies, and experimental methods. The study highlights how computational methods enhance drug discovery efficiency, while omics technologies provide systematic frameworks for investigating drug mechanisms. The integration of these advanced approaches has enabled more diverse and personalized treatment strategies, though challenges remain in drug development complexity, cost-effectiveness, and operational feasibility.

A drug-resistant type of bacteria that has adapted to health care settings evolved in the past several years to weaponize an antimicrobial genetic tool, eliminating its cousins and replacing them as the dominate strain. University of Pittsburgh School of Medicine scientists made the discovery when combing through local hospital data – and then confirmed that it was a global phenomenon.