Researchers from The University of Osaka found that macrophages use microautophagy, mediated by Rab32-positive lysosome-related organelles, to directly engulf damaged mitochondria and other organelles. This was discovered to be independent of macroautophagy. Key factors in this process include Rab32 GTPase, PI(3,5)P₂, ubiquitination, and p62/SQSTM1. By clearing mitochondria, microautophagy promotes metabolic reprogramming toward glycolysis, supporting M1 macrophage polarization. Loss of Rab32/38 disrupts this process, highlighting microautophagy’s role in regulating macrophage function.

From medicine to electronics and optics, new materials developed by scientists at Kaunas University of Technology (KTU) can be applied in various fields where cleanliness, precision, and durability are essential. They stand out not only for their functionality but also for their sustainability: they are made from renewable raw materials, and no solvents are used during production.

The natural phenomenon of upwelling, which occurs annually in the Gulf of Panama, failed for the first time on record in 2025. A study led by scientists from the Smithsonian Tropical Research Institute (STRI) indicates that the weakening of the trade winds was the cause of this event. This finding highlights the climate’s impact on fundamental oceanic processes and the coastal communities that depend on them

Study coordinated by Ca’ Foscari University of Venice opens new perspectives on the complex behaviour of prehistoric human populations. It’s the first time that the indigotin molecule has been found on such ancient artefacts, demonstrating the processing of Isatis tinctoria L., a non-edible plant: hypotheses are open on its use as a dye or medicine.