This review highlights the growing interest in ginsenosides, especially Compound K (CK), as potential anti-aging agents due to their promising effects on skin health. Rare ginsenoside Compound K, a highly active deglycosylated metabolite of ginsenosides, demonstrates significant anti-aging properties. This review discusses the anti-skin aging mechanisms of Compound K, including improving skin barrier, protecting against photoaging, supplementation of extracellular matrix, regulation of autophagy, resistance to inflammation, activation of longevity gene family, regulation of mitochondrial dynamics and bioenergy, and antioxidant Journal Pre-proof repair of cell damage.In addition, the physicochemical properties and transdermal absorption effects of CK were described in detail. In the end, the article emphasizes the need for further research into the molecular mechanisms of Compound K's anti-aging effects and its potential applications in developing natural anti-aging skincare products.

Collagen, a primary structural protein in the mammalian extracellular matrix, plays a crucial role in supporting, repairing, and protecting tissue cells. With sources ranging from natural extraction to artificial synthesis, collagen has significant applications in cosmetics, pharmaceuticals, medicine, and the food industry. Its unique structure, excellent biocompatibility, and low antigenicity make it highly valuable in the cosmetic industry, where it is widely used in skincare products and medical aesthetic procedures to combat skin aging and enhance skin health. This paper reviews the sources and types of collagen utilized in cosmetics, explores its effects on skin, and discusses its future prospects in dermatology and cosmetic applications.

On October 21, 2024, the research team led by Professor Lv Han from Capital Medical University Affiliated Beijing Friendship Hospital, in collaboration with the team led by Professor Jiang Jiehui from Shanghai University, conducted a population-based cohort study to investigate the long-term effects of unhealthy lifestyles, metabolic abnormalities, and other risk factors on brain aging. The results demonstrated that these risk factors significantly accelerate brain aging, and the researchers proposed key strategies to promote brain health. The study was published in the Research under the title "Discovery of High-Risk Clinical Factors That Accelerate Brain Aging in Adults: A Population-Based Machine Learning Study" (Research 2024; 7: Article 0500. DOI: 10.34133/research.0500).

An FFG-funded consortium of Austrian research groups from the University of Vienna, MedUni Vienna and Technikum Wien together with company partner DOC Medikus GmbH has developed an innovative bioanalytical test system for radiopharmaceutical drug candidates for cancer diagnosis and therapy. It does not require any animal testing at all and enables automated, fast and highly precise analyses. The new method was presented in detail in the renowned Journal of Nuclear Medicine.

Gases used in anaesthesia are potent greenhouse gases, and their total global impact has not previously been known. A study published in The Lancet Planetary Health led by Lund University shows that greenhouse gas emissions from anaesthetic gases have decreased by 27% over the last ten years. By swapping out the anaesthetic gas with the highest climate impact, the climate impact of anaesthetic gases could have been reduced by a further 69%.

An experimental drug appears to reduce the risk of Alzheimer’s-related dementia in people destined to develop the disease in their 30s, 40s or 50s, according to the results of a study led by the Knight Family Dominantly Inherited Alzheimer Network-Trials Unit (DIAN-TU), which is based at Washington University School of Medicine in St. Louis. The findings suggest – for the first time in a clinical trial – that early treatment to remove amyloid plaques from the brain many years before symptoms arise can delay the onset of Alzheimer’s dementia.

A recent study conducted by researchers from Arizona State University has uncovered alarming levels of Fusarium mycotoxins in illicit cannabis samples seized in Arizona and California. The study found that 16% of the 118 samples tested positive for harmful mycotoxins, posing potential health risks to consumers. This groundbreaking research highlights the unregulated and dangerous nature of black-market cannabis.