A light-activated probe reveals TB immune system evasion mechanisms
Peer-Reviewed Publication
Updates every hour. Last Updated: 12-Sep-2025 10:11 ET (12-Sep-2025 14:11 GMT/UTC)
Tuberculosis (TB) is an infectious disease that kills more than a million people worldwide every year. The pathogen that causes the disease, Mycobacterium tuberculosis, is deadly in part because of its complex outer envelope, which helps it evade immune responses of infected hosts. In an ACS Infectious Diseases paper, researchers developed a chemical probe to study a key component of this envelope. Their results provide a step toward finding new ways of inactivating the bacterium.
A team of researchers from the University of Chicago, in collaboration with researchers from the University of Pittsburgh, has identified a novel oncometabolite that accumulates in tumors and impairs immune cells’ ability to fight cancer.
The study highlights the transformative potential of the Rights of Nature, which views nature as a rights-bearing entity, not merely an object of regulation and subjugation by extractive industries. The Llurimagua case—a dispute over a mining concession in Ecuador’s cloud forest—illustrates this approach, providing a unique opportunity to rethink Earth system governance.
The paper was authored by a diverse team of researchers from the University of Vermont, Universidad de los Hemisferios, Centro Jambatu de Investigación y Conservación de Anfibios, Coordinadora Ecuatoriana de Organizaciones para la Defensa de la Naturaleza y el Medio Ambiente (CEDENMA), and the Garrison Institute.
Key Findings of the article:
Nature's Rights: Ecuador's recognition of Nature's Rights represents a monumental shift in Earth system governance, embedding humans within dynamic ecological processes and advancing Earth system law more pluralistically.
Community Action: The resistance to mining in Intag Valley exemplifies the power of community action and international solidarity in pursuing planetary health equity and justice.
Pluriversality: The concept of pluriversality challenges the Core’s hegemony of knowledge, emphasizing care, stewardship, and equitable coexistence with all life forms.
Legal Precedents: The Llurimagua case, involving two frog species and the Junín community, sets a robust legal model for harmonizing the ecosphere and ethnosphere, ensuring the health of both people and the planet.