NSF-funded research heads to the international space station on NASA's SpaceX CRS-32 mission
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Updates every hour. Last Updated: 12-Sep-2025 02:11 ET (12-Sep-2025 06:11 GMT/UTC)
Colorectal cancer (CRC) is a globally prevalent malignancy with high morbidity and mortality rates, closely linked to aberrant epigenetic modifications. Among these, pseudouridine (Ψ), one of the most abundant RNA chemical modifications, plays a pivotal role in tumorigenesis by regulating mRNA stability, translation efficiency, and splicing processes. Recent studies have demonstrated that the small-molecule inhibitor Pyrazofurin, targeting the pseudouridine synthase DKC1, exhibits significant anti-tumor activity, suggesting Ψ modification as a promising therapeutic strategy for CRC. However, the dynamic changes and clinical implications of transcriptome-wide Ψ modifications in CRC remain poorly understood.
Scientists found Escherichia albertii, an emerging foodborne pathogen, in 64% of retail chicken meat in Bangladesh. The study revealed widespread contamination, cross-contamination during processing and high antimicrobial resistance. The findings highlight urgent public health risks and the need for improved hygiene, antibiotic regulations and global monitoring.
A novel approach called Counterfactual Synthetic Minority Oversampling Technique (SMOTE) has been developed to tackle the persistent issue of imbalanced data in healthcare. Traditional models trained on imbalanced datasets often overlook rare but critical conditions, such as diseases, leading to biased predictions. By combining SMOTE with counterfactual generation, Counterfactual SMOTE creates synthetic data points near decision boundaries while minimizing noise. This method significantly enhances model performance, enabling better detection of rare conditions without overwhelming false positives. Tested across 24 healthcare datasets, Counterfactual SMOTE outperforms existing methods, offering a robust solution for improving medical diagnostics and extending to other fields.
A cross-sectional study was conducted among 423 adolescents enrolled from 10 high schools in Harare, Zimbabwe. The Osaka Metropolitan University-led team used a questionnaire to collect sociodemographic data, food habits, nutrition knowledge, and physical activity.