Prebiotics might be a factor in preventing or treating issues caused by low brain GABA
Peer-Reviewed Publication
Updates every hour. Last Updated: 29-Dec-2025 11:11 ET (29-Dec-2025 16:11 GMT/UTC)
GABA, or gamma-aminobutyric acid, is an amino acid functioning as the principal inhibitory neurotransmitter that can act on the brain to slow or stop the reception of certain signals to the brain, leading to a calmer and more relaxed state. Low GABA levels in the brain have been associated with neurological disorders and diseases like depression, Alzheimer's or epilepsy. Recently, there has been a push towards understanding more about the gut’s influence on mood, behavior and mental health, as well as what foods might fuel or hinder a healthy mind. Researchers set to work on determining whether brain GABA levels can be increased through dietary additions with the aim of modulating the gut bacteria present in an individual to bypass the blood-brain barrier, a barrier in which it is not proven yet GABA can pass through.