Macrophage-driven U2AF1 promotes heart repair after heart attack via Yap1 splicing
Peer-Reviewed Publication
Updates every hour. Last Updated: 23-Dec-2025 19:11 ET (24-Dec-2025 00:11 GMT/UTC)
A new study in Engineering reveals how macrophage-released U2AF1 aids heart repair after heart attack by steering Yap1 splicing toward the pro-angiogenic Yap1-2γ isoform, offering a potential biomarker and therapeutic target for improving cardiac recovery.
C. Ola Landgren, M.D., Ph.D., received HealthTree Foundation’s prestigious 2025 Innovation Award for his work in developing CORAL, a new research tool that leverages AI to predict individual outcomes and guide treatment decisions in patients with multiple myeloma.