People with temporal lobe epilepsy in particular often wander around aimlessly and unconsciously after a seizure. Researchers at the University Hospital Bonn (UKB), the University of Bonn, and the German Center for Neurodegenerative Diseases (DZNE) have identified a neurobiological mechanism that could be responsible for this so-called post-ictal wandering and potentially other postictal symptoms. According to their hypothesis, epileptic seizures are not directly responsible for post-ictal symptoms, but rather seizure-associated depolarization waves, also known as spreading depolarization (SD). The results of the studies have now been published in the journal Science Translational Medicine.

Until now, most evidence for PTSD-like symptoms in ASD has relied on self-reports, leaving the underlying brain mechanisms unclear. In a new study, researchers led by Professor KIM Eunjoon at the Institute for Basic Science (IBS) have uncovered how an ASD-related mutation in the Grin2b gene, which encodes the GluN2B subunit of NMDA receptors, disrupts brain circuits that normally extinguish fear. Their findings, published in Science Advances, provide the first detailed mechanistic explanation for why ASD increases PTSD risk.

A survey study of families with puppies in the U.K. has identified multiple mental health challenges alongside benefits of ownership for adults and kids alike, suggesting that a mental health boost should not be the main motivator behind getting a puppy. Rowena Packer of the Royal Veterinary College, U.K., and colleagues present these findings in the open-access journal PLOS One on September 17, 2025.

Two healthcare workers get COVID-19 vaccinations on the same day. Both show strong antibody responses initially, but six months later one stays healthy while the other contracts the virus. A new study published in Science Translational Medicine could help explain this difference. Researchers tracked individuals’ antibody levels after vaccinations and identified four distinct patterns of immune response after the first booster vaccination. Notably, the group that started with the highest antibody levels but experienced a faster decline were infected earlier. People with lower blood levels of IgA(S) antibodies, which protect the nose and throat, were also at higher risk. The findings suggest that monitoring how antibody levels change over time could assist in identifying individuals at greater risk of infection.