Hidden brain waves as triggers for post-seizure wandering
Peer-Reviewed Publication
Updates every hour. Last Updated: 5-Oct-2025 17:11 ET (5-Oct-2025 21:11 GMT/UTC)
People with temporal lobe epilepsy in particular often wander around aimlessly and unconsciously after a seizure. Researchers at the University Hospital Bonn (UKB), the University of Bonn, and the German Center for Neurodegenerative Diseases (DZNE) have identified a neurobiological mechanism that could be responsible for this so-called post-ictal wandering and potentially other postictal symptoms. According to their hypothesis, epileptic seizures are not directly responsible for post-ictal symptoms, but rather seizure-associated depolarization waves, also known as spreading depolarization (SD). The results of the studies have now been published in the journal Science Translational Medicine.
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