Your lungs in chip form
Kyoto UniversityPeer-Reviewed Publication
Kyoto, Japan -- Respiratory infections such as COVID-19 have been responsible for numerous pandemics and have placed a substantial burden on healthcare systems. Such viruses can cause significant damage to our lungs, especially to the proximal region, or airway, and distal region, also known as the alveoli.
The responses of different lung regions to such infections are varying and complex, so accurately replicating them using traditional models, such as animals and simple in vitro systems, poses a challenge.
To solve this problem, a team of researchers at Kyoto University has developed a micro physiological system, or MPS, capable of emulating different regions of human lungs. Specifically, their device can simulate the airway and alveoli to investigate viral pathologies. Coupled with isogenic iPSCs, the team is preparing for more personalized and accurate treatment of respiratory diseases.
- Journal
- Nature Biomedical Engineering
- Funder
- Japan Science and Technology Agency, Japan Society for the Promotion of Science, Japan Agency for Medical Research and Development