Cartilage and bone development: three paths to skeleton formation
Peer-Reviewed Publication
Updates every hour. Last Updated: 30-Apr-2025 22:08 ET (1-May-2025 02:08 GMT/UTC)
In vertebrates, the skeleton of different regions of the body arises from different precursor cells. Researchers at the University of Basel have now discovered that these skeletal cells do not just differ in their developmental origin, but also in their gene regulation – which may be a key to the vertebrates’ evolutionary success story.
Molecular biologist Yali Dou, PhD, holder of the Marion and Harry Keiper Chair in Cancer Research and professor of medicine and cancer biology at the Keck School of Medicine of USC, has been elected a fellow of the American Association for the Advancement of Science (AAAS). She is one of seven USC faculty members in the 2025 cohort of new fellows. Dou, the associate director for basic research at USC Norris Comprehensive Cancer Center, is a recognized leader in the study of epigenetics, the mechanisms that enable the singular instructions in DNA to be expressed as myriad cell and tissue types. She has made major contributions to the fundamental understanding of a family of enzymes that plays a vital role in fetal development by altering the coiled chromatin, which packages DNA to fit in the chromosomes of a cell’s nucleus, so that genes are activated. Because mutations of the founding member of this family of enzymes can also spur leukemia, they are known as mixed-lineage leukemia proteins, or MLL. MLL enzymes are among the most frequently mutated genes in cancer.
A group of researchers including scientists of the Earth-Life Science Institute (ELSI) at Institute of Science Tokyo have uncovered a surprising role for calcium in shaping the building blocks of life. Their study reveals that calcium ions help determine the molecular "handedness" (chirality) of tartaric acid polymers—an essential feature of biological molecules like DNA and proteins. This discovery sheds light on how life's uniform molecular structures may have first emerged on early Earth. In a twist on traditional theories, the researchers suggest that simple polyesters, in addition to peptides or nucleic acids, could have adopted this crucial trait on early Earth, offering a fresh perspective on life’s chemical origins.