Lung cancer is the leading cause of cancer-related mortality worldwide. Elucidating the molecular programs that enable tumor cells to evade regulated cell death and anti-tumor immune responses is essential for developing effective therapeutic strategies. In this study, Wang and colleagues employ a series of genetically engineered non-small cell lung cancer mouse models, high-throughput lipidomics assays, and functional perturbation experiments to uncover how tumor cells adapt metabolically to escape ferroptosis and reprogram the tumor microenvironment for CD8⁺ T cell dysfunction.

Whether great minds think alike is up for debate, but the collaborating minds of two people working on a shared task process information alike, according to a study published November 25^th in the open-access journal PLOS Biology by Denise Moerel and colleagues from Western Sydney University in Australia.

The research by geobiologist Eric Boyd examines the impact of seismic activity on underground microbial communities.

Adipose tissue is a crucial energy-regulating organ in mammals, responsible not only for storing excess energy but also participating in body temperature maintenance and metabolic balance.

In a study now published in iScience, researchers from the University of Vienna (Austria), National Institute of Technology - Wakayama College (NITW; Japan), and Shimane University (Japan) present the largest cephalopod genome sequenced to date. Their analyses show that the vampire squid has retained parts of an ancient, squid-like chromosomal architecture, and thus revealing that modern octopuses evolved from squid-like ancestors.

Four major turning points around age nine, 32, 66 and 83 create five broad eras of neural wiring over the average human lifespan. Typical adolescent brain development lasts until our early thirties on average, when the adult era of neural wiring finally emerges. 

Estimating the multigenerational effects of chiral pesticide metabolites is essential for fully understanding their ecological impacts. This study demonstrated that S-o,p'-DDD accumulated preferentially in adult zebrafish and transferred more efficiently to their offspring compared to the R-enantiomer, leading to pronounced developmental defects and endocrine disruption across both generations. Molecular docking against key thyroid-related proteins provided a mechanistic explanation for this stereospecific toxicity. These findings suggest that evaluating only racemic mixtures may underestimate real-world hazards.