Seven-transmembrane (7TM) proteins are large, complex molecules with important biological functions, but high-resolution NMR structural data for 7TM proteins has eluded researchers. Recently, a team from Japan achieved high-resolution solid-state NMR (SSNMR) data for fully protonated SzR1, a 7TM protein, in a fully hydrated lipid bilayer utilizing ultrafast magic angle spinning (MAS) NMR at 160 kHz using a 0.4mm rotor.

A new review in Medicine Plus outlines a transformative paradigm for luminal cancers using engineered microbe-based micro/nanorobots. Deployed via oral, suppository, or intracavitary routes, these living platforms bypass physiological barriers, colonize tumor niches, continuously synthesize therapeutics, and remodel the tumor microenvironment. Merging microbial adaptability with synthetic biology, they usher in an era of persistent, spatially controlled intervention.

A new review in Medicine Plus traces the evolution of mRNA lipid nanoparticles (mRNA-LNPs) from prophylactic vaccine vehicles to programmable therapeutic platforms. The authors detail clinical and preclinical progress across infectious disease, cancer, autoimmunity, rare genetic disease and tissue repair, while identifying key translational hurdles including extrahepatic targeting, repeat-dose immunogenicity, off-target editing risks, and scalable manufacturing.