This study revealed for the first time the molecular mechanism of histone methyltransferase KMT5C mediated H4K20me3 modification, recruited RNA/DNA binding protein EWSR1, formed an "epigenetic metabolism" regulatory axis, synergistically inhibited the expression of fatty acid metabolism key gene ACADM, and ultimately promoted the progression of clear cell renal cell carcinoma (ccRCC). At the same time, studies have confirmed that KMT5C inhibitor A-196 combined with sunitinib, a first-line targeted drug, can significantly enhance the anti-tumor effect, which provides a new strategy to overcome the resistance of ccRCC.

A single molecular regulator may help explain how pear skin loses red pigment while retaining green color as fruit matures. 

Researchers at Pennington Biomedical Research Center have identified a key brain mechanism that connects environmental temperature with appetite and energy balance, offering new insight into how external conditions can shape body weight over time.

The findings, published in the journal Communications Biology, highlight a group of neurons that act as a critical integration point between thermoregulation – the body’s ability to maintain its internal temperature – and the systems that control hunger and metabolism.

- Delivers world-leading performance using a novel Ni/Co heterostructure electrode.

- Cuts material costs by 99% compared to noble-metal electrodes (e.g., platinum), driving the successful domestic sourcing of key materials.

- Published in Advanced Science (IF 14.1), a top-tier international journal in chemistry and materials science.

Skin cancer is a global health challenge, with nearly 1.5 million new cases diagnosed in 2024 according to World Health Organization (WHO) data. In response, the University of Alicante (UA) and the Sant Joan d’Alacant University Hospital have collaborated to launch MEL-IA (MobilE skin Lesion dIAgnosis), an artificial intelligence system designed to automate the classification of skin lesions. The MEL-IA system achieves an overall accuracy of 86 %.

In 287 Han Chinese adults with HIV-1, UGT1A1*6 was significantly associated with higher dolutegravir (DTG) trough concentrations, with homozygous carriers showing the strongest effect. Compound UGT1A1*6/*60 and UGT1A1*6/*28/*60 genotypes and low body weight were independent risk factors for elevated DTG levels. No significant associations were found between DTG trough concentrations and viral suppression or adverse effects. 

Gait is a fundamental activity of daily living that reflects physical and cognitive function. Researchers studied 421 older individuals and found that mild cognitive impairment was associated with slower gait speed during both comfortable and fast walking, even after accounting for frailty. The findings add evidence that gait speed, already used to assess physical function, may also help assess cognitive function and support future cognitive screening in daily life.