Epilepsy is among the most common neurological conditions, marked by unpredictable seizures, accidents and injuries, reduced quality of life, stigma and—in the worst case—premature death. But a program—developed over several years by a Case Western Reserve University-led research team—that teaches people with epilepsy how to “self-manage” their disorder is showing positive results. The program has been found to help people with epilepsy reduce related health complications and improve their mood and quality of life, according to a new study recently published in the peer-reviewed journal, Epilepsy & Behavior.

CRISPR-based gene editing holds great promise, but off-target effects remain a major concern, especially across diverse genetic backgrounds. A new study presents a web-based tool that enhances off-target site prediction by incorporating individual genetic variants. Developed using the human genome and pepper plant cultivars, the tool improves accuracy at the haplotype level. This user-friendly, login-free platform offers researchers a powerful way to personalize and safeguard genome editing applications across fields.

Improved treatment regimens have increased the life expectancy of individuals infected with HIV. However, these individuals are at a higher risk of developing other comorbidities—one such condition that has been debated upon is osteoarthritis (OA). Now, researchers from Shanghai Jiaotong University have uncovered a link between protease inhibitors—drugs utilized in HIV management—and the acceleration of OA development.