Mitochondria are highly dynamic organelles that adapt to cellular stress and metabolic demands through processes such as fission, fusion, mitophagy, and transport, all of which are vital for maintaining cellular signaling and metabolic homeostasis. Fission facilitates mitochondrial division and biogenesis, while fusion enhances mitochondrial fitness and metabolic flexibility by mitigating damage. Together, these processes play a critical role in regulating cellular stress responses and apoptosis. Dysregulation of mitochondrial dynamics has been linked to impaired development and cancer progression, including breast cancer metastasis. A comprehensive understanding of mitochondrial dynamics in breast cancer progression is essential for advancing precision medicine. This review delves into the intricate molecular mechanisms governing mitochondrial biogenesis, fission, fusion, and mitophagy, with a particular focus on the role of mitophagy in maintaining mitochondrial homeostasis and its connection to metastasis progression. Furthermore, it discusses potential therapeutic strategies targeting mitochondrial dynamics and highlights the critical steps necessary to translate these approaches into clinical trials.

A UCLA study shows that removing a modest $45 out-of-pocket fee significantly improved access to 3D mammography,  increasing overall usage several percentage points and particularly benefitting underserved patient populations,

A new handheld tuberculosis testing device significantly improves the detection of HIV, a common co-infection which can prevent TB from being detected by traditional tests. Powered by a beetle-inspired chemical reaction and requiring no electricity, lab or trained staff, the ASTRA device is designed to offer accurate, same day diagnoses anywhere in the world.