Healthy hearts are adaptable, and heartbeats exhibit complex variation as they adjust to tiny changes in the body and environment. Mass General Brigham researchers have applied a new way to measure the complexity of pulse rates, using data collected through wearable pulse oximetry devices. The new method, published in Journal of the American Heart Association, provides a more detailed peek into heart health than traditional measures, uncovering a link between reduced complexity and future cognitive decline.

In a groundbreaking study led by a multinational team of experts, researchers at National Jewish Health and their collaborators in Colorado, Illinois, Taiwan and Israel have introduced a new term to the medical lexicon: silicosarcoidosis. This novel designation describes cases where patients’ lung tissue exhibits overlapping features of both silicosis and sarcoidosis, two serious pulmonary diseases linked to occupational exposure to respirable crystalline silica (RCS) commonly found in construction, mining, and engineered stone fabrication.

New Haven, Conn. — A sweeping new study led by researchers at the Yale School of Public Health (YSPH) reveals stark disparities in life expectancy across U.S. states and Washington, D.C. over the past century – offering new insights into how a region’s public health policies, social conditions, and environmental factors can shape people’s lifespans.

Analyzing more than 179 million deaths between 1969 and 2020, the multi-institutional research team traced life expectancy trends by birth cohort — a more precise measure for following the life experiences of a population than traditional year-by-year summaries of mortality, which represent a mix of many generations.

The study, which appears in JAMA Network Open, found that some states saw dramatic gains in life expectancy, while others, particularly in the U.S. South, experienced little or no improvement over an entire century.

Researchers at Washington University in St. Louis led a study of nearly 30,000 students that shatters misconceptions about eating disorders, a common and misunderstood condition.

In a new study, researchers from Mass General Brigham identified a natural “brake” within the innate immune system: the inhibitory receptor Siglec-E (SigE) and its human counterparts, Siglec-7 and Siglec-9. This receptor helps prevent overactivation of immune cells that drive rejection. When this brake is missing, inflammation worsens, leading to faster rejection in preclinical models. Importantly, transplant patients with higher levels of Siglec-7 and Siglec-9 showed better graft survival, highlighting this pathway as a promising target for new therapies. Results are published in Science Translational Medicine.