Aging often brings metabolic troubles, and a new study in Engineering may explain why. Scientists found a special sugar-modified antibody called fucosylated IgG builds up in aging fat tissue. It worsens inflammation and scarring while weakening fat’s normal function. This discovery points to a new way to ease age-related metabolic problems by adjusting this antibody’s sugar structure, giving fresh hope for healthy aging.

B lymphoma remains tough to treat with current cell therapies due to high costs and limited antigen targeting. A new study in Engineering compares two live-cell glycocalyx engineering methods to boost immune cells against B lymphoma. By equipping NK and CAR-T cells with CD22-targeting glycans, researchers enhance tumor recognition and killing. This transgene-free strategy offers a practical, cost-efficient path to better adoptive cell therapies.

Chinese herbal medicines have given birth to many classic drugs, but their complex ingredients and unclear mechanisms slow new drug development. A new study in Engineering proposes phenotype–target coupled drug screening, combining phenotype-based and target-based discovery with AI, multiomics, and organ-on-chip models. This efficient framework helps locate active compounds, clarify targets, and boost success rates for herbal drug research and development.