The Regenerative Medicine Project at our institute is advancing therapeutic strategis for various diseases by introducing a range of modifications to human induced pluripotent stem (iPS) cells.

We are pleased to announce that we have successfully established iPS cells with doubled chromosomes (tetraploid iPS cells) via cell fusion. By differentiating these tetraploid iPS cells into cardiomyocytes, we succeeded in developing a technology that replicates the chromosome doubling that occurs naturally in vivo during cardiomyocyte maturation, thereby enhancing cardiac function.

The research findings were published online in the British scientific journal Communications Biology on Monday, August 17, 2026.

October 26–27 | Dubai

Dr. Alex Aliper, Co-founder and President of Insilico Medicine, has been invited to attend the Dubai AI Festival 2026 at the Dubai World Trade Centre (DWTC).

October 26–27 | Hong Kong

Dr. Feng Ren, Co-CEO and Chief Scientific Officer of Insilico Medicine, has been invited to attend the 2026 Global Healthcare Innovation Summit (GHIS 2026) at the Grand Hyatt Hong Kong.

October 28–30 | Seoul  

Dr. Jue Wang Global Head of Business Development at Insilico Medicine, has been invited to attend BioPlus-Interphex Korea 2026 (BIX 2026) at COEX in Seoul.

October 29 | Suzhou  

Dr. Feng Ren, Co-CEO and Chief Scientific Officer of Insilico Medicine, has been invited to attend the 6th SAPA-China 2026 Healthcare Industry Conference at the Suzhou Shishan International Conference Center.

October 29–30 | Shenzhen

Dr. Alex Aliper, Co-founder and President of Insilico Medicine, has been invited to attend the 2026 Tencent Global Digital Ecosystem Summit, held in Hall 18 at the Shenzhen World Exhibition & Convention Center.

Hiroshima University researchers investigated the effects of hydrogen supplementation on sleep quality in healthy human volunteers. While hydrogen supplementation had no significant effect compared to a placebo, individuals in the hydrogen-supplementation group reporting better sleep quality were discovered to have a lower abundance of hydrogen producing bacteria in their gut microbiome.

Grapevine trunk diseases threaten sustainable viticulture, and effective chemical control has been lacking since sodium arsenite was banned because of its risks to human health, while wine lees remain an underexploited by-product of the wine industry. Researchers have now developed an integrated bioprocess that upgrades lees into antifungal biomolecule mixtures, combining fermentation design with Saccharomyces monocultures and sequential inoculation with non-Saccharomyces strains.

A new prospective study from Japan explored whether fish consumption before and during pregnancy is linked to hypertensive disorders of pregnancy, including gestational hypertension and preeclampsia. Researchers analyzed data from women in Japan, examining fish, n-3 and n-6 polyunsaturated fatty acid (PUFA) intake across different stages of pregnancy. The results reveal an intriguing pattern that may have implications for preconception and prenatal nutrition.

Agitation is a common complication of traumatic brain injury, yet there are no standardized approaches to managing it. In a recent scoping review, a research team in the UK examined 13 studies on agitation management published over the past decade, identifying promising pharmacological and non-pharmacological strategies. Their findings highlight the need for more precise measures and larger clinical trials to guide safer, evidence-based care.

Pancreatic cancer is one of the most aggressive and difficult-to-treat cancers. One reason for its resistance to therapy is the dense tissue surrounding the tumor, which acts as a protective barrier and suppresses the immune response. Researchers at the Karlsruhe Institute of Technology (KIT) have now identified a molecular mechanism that regulates this tumor-supporting environment. At the heart of this mechanism is CD44, a molecule that controls the behavior of cancer-associated fibroblasts, specialized connective tissue cells that play a crucial role in shaping the tumor microenvironment.The results have been published in Cell Death & Disease (DOI: 10.1038/s41419-026-09155-5).