SOX2: a key player in prostate cancer progression and treatment resistance
Peer-Reviewed Publication
Updates every hour. Last Updated: 10-Oct-2025 20:11 ET (11-Oct-2025 00:11 GMT/UTC)
Prostate cancer remains a global health challenge, ranking as the second most common malignancy among men. While early-stage disease can be effectively managed, advanced forms—particularly metastatic castration-resistant prostate cancer (mCRPC)—pose significant therapeutic hurdles. A growing body of evidence highlights the pivotal role of SOX transcription factors, with SOX2 emerging as a central driver in tumor growth, spread, and resistance to therapy.
Air pollution from oil and gas is causing 91,000 premature deaths and hundreds of thousands of health issues across the United States annually, with Black, Asian, Native American and Hispanic groups consistently the most affected, finds a major new study led by researchers at UCL and the Stockholm Environment Institute (SEI).
While 42 states require public school students to take a sexual education course that covers at least one topic within this subject between kindergarten and high school, only 19 states mandate that this instruction be medically accurate—and 5 of those states only require medical accuracy for specific topics, according to a new study in the American Journal of Public Health. The study also found that 34 states that mandate sexual education in public schools require instruction on abstinence, a method that has consistently proven to be ineffective or harmful to adolescent sexual health, but continues to be embraced and funded by the federal government. Thirty-four states also allow parents to opt their children out of receiving any sexual education instruction, while five states require parents to opt in for their children to receive this instruction.
A University of Massachusetts Amherst kinesiologist has received a five-year, $2 million grant from the National Institutes of Health (NIH) to advance his research on how myosin molecules—molecular motors crucial for muscle contraction— work together to drive different processes within cells.