Researchers at Oregon Health & Science University have uncovered a key reason why immunotherapy has largely failed in pancreatic cancer — and identified a promising strategy to overcome that resistance. 

The study, published in the journal Immunity, shows that pancreatic tumors actively reshape their immune environment by co‑opting regulatory immune cells that normally shut down tumor-killing cells. By reprogramming those cells, the research reveals a potential pathway to make immunotherapy effective against one of the deadliest and most treatment‑resistant cancers. 

New research from the University of Maryland, Baltimore County (UMBC) reveals that inputs from the dorsal and ventral hippocampus converge on the same neurons in the nucleus accumbens, where they amplify each other. The study shows how the brain integrates spatial and contextual memory with motivation and reward to drive goal-directed decisions. Published in the Journal of Neuroscience, it challenges the idea that these pathways operate separately and offers insight into motivation-related disorders such as depression, addiction, and anxiety.

The well-being of a supervisor is reflected through supervisor-subordinate relationships in employee motivation and performance, and consequently, in the company’s competitiveness. In his doctoral research at the University of Vaasa, Finland, Project Researcher Jussi Tanskanen demonstrates that an exhausted leader lacks the resources to maintain high-quality relationships with subordinates, leading to a collapse in employee dedication. This phenomenon is particularly pronounced in today’s intensive work environment and remote work settings.

A research team led by Sir Run-Run Shaw Hospital, Zhejiang University School of Medicine, has published a comprehensive review in ExRNA that sorts out the diverse roles of extracellular vesicle-associated RNAs (EV-RNAs) in the development and progression of inflammatory bowel disease (IBD). By integrating the latest findings from multi-omics studies and animal experiments, the review points out that EV-RNAs can serve as non-invasive biomarkers for early IBD detection and disease monitoring, and also hold great potential as targets for next-generation targeted therapies. This work provides a solid theoretical basis for advancing personalized precision treatment for the millions of IBD patients worldwide suffering from this chronic recurrent gastrointestinal disorder.