Crystal structure prediction (CSP) of organic molecules is a critical task, especially in pharmaceuticals and materials science. However, conventional methods are computationally intensive and time-consuming. Now, researchers from Japan have developed a new workflow: SPaDe-CSP that accelerates CSP by machine learning-based prediction of most probable space groups and crystal densities and employing an efficient neural network potential for structure refinement. It achieved faster and more reliable CSP than conventional methods.

A recent review by Dr. Sanjay Singhal from Dr. Ram Manohar Lohia Institute of Medical Sciences examines aerosol drug therapy (ADT) practices in acute respiratory distress syndrome (ARDS). The Aero-in-ICU study found that ADT is frequently used in ARDS, with bronchodilators delivered mainly via jet nebulizers. Despite a strong physiological rationale, randomized controlled trials have not confirmed clinical benefits. The findings highlight the gap between clinical evidence and practice, underscoring the need for further research.

Four distinct subgroups of polycystic ovary syndrome (PCOS) have been identified in an international study published in Nature Medicine by researchers from Karolinska Institutet, among others. The results open up for more tailored treatments for the millions of women living with the disease worldwide.