Caloric restriction (CR) is an effective dietary intervention that delays aging and improves metabolic health. Previous studies have reported that lithocholic acid (LCA), a secondary bile acid, increases significantly in serum during CR. LCA has been shown to mimic the anti-aging effects of CR across multiple model organisms, including elevating muscle NAD⁺ levels, enhancing grip strength and exercise endurance in aged mice, and extending lifespan in nematodes and fruit flies.

Researchers have found a new way to trick cancer cells into consuming even more sugar than usual and, at the same time, block their backup fuel source—fat. By attacking both fuel sources at once, the experimental drug puts cancer cells under so much stress that many of them die. They demonstrated the drug’s effectiveness at treating an aggressive form of melanoma in mice.

The meningococcal B (MenB) vaccine could provide protection against more than one disease, with new research linking it to a significant reduction in the risk of gonorrhoea in young people in parts of Australia.

Salidroside, the key active compound of Rhodiola plants with anti-hypoxia and anti-fatigue properties, is highly valued in medicine, health products, and cosmetics. A new study demonstrates an efficient dual-enzyme cascade system combining sucrose synthase and glycosyltransferase that achieves one-pot biosynthesis of salidroside with 90% conversion rate. Through solubility enhancement and thermostability engineering, the system produces 13.61 g/L salidroside within just 10 hours, establishing a practical platform for industrial-scale green production.