As demands for high-quality wound management, health monitoring, and intelligent interaction rise, e-skin—designed to replicate human skin’s flexibility, self-healing ability, and multimodal sensing functions—has steadily emerged as a prominent new research focus. Here, we present a natural biomass-derived multimodal conductive e-skin patch (CCMP) that fabricated by integrating aminated multi-walled carbon nanotubes (MWCNTs-NH2) and dopamine (DA) into carboxymethyl starch (CMS)/carboxymethyl chitosan (CMCS)/polyvinyl alcohol (PVA) matrix through supramolecular interactions assembly. The CCMP demonstrated remarkable electrical conductivity (24.1 S/m), efficient photothermal conversion (with a heating time constant τ_s = 66.66 s), strong antioxidant activity (>96.53%), effective antibacterial performance, hydrophobicity, electromagnetic shielding capability, as well as high sensitivity to temperature (TCR = −8.58 %/°C), strain, and electrical signals. Furthermore, the CCMP also demonstrated ultra-high swelling properties. Notably, the CCMP presented easy re-shaping and ultra-high swelling capacity (water sorption reached 1374%), promoting the rapid absorption of tissue exudate. Meanwhile, the CCMP can significantly promote wound healing and reduce pro-inflammatory factor levels, achieving an exceptional 99% healing rate within 14 days. We additionally integrate a portable wireless wearable sensing system that can transmit real-time wound status micro-motion and multimodal physiological signals (temperature, stress-strain, respiration, motion, and bioelectric signals) via Bluetooth to computers or mobile devices, thus achieving integrated skin-interfacing wearable bioelectronics and smart wound healing. Overall, this study pioneers a novel approach for wireless wound monitoring system, advancing human-friendly e-skin patch development from single-functional devices to a human-machine-environment intelligent symbiosis system.

A growing body of scientific insight is drawing attention to cellular senescence as a central force in the progression of intervertebral disc degeneration (IDD), a leading contributor to chronic low back pain worldwide. This condition, which significantly impacts mobility and quality of life, is now increasingly understood through the lens of aging-related cellular changes that disrupt the delicate balance of spinal tissues.

A new review highlights the remarkable importance of selenoproteins, a specialized group of molecules that, despite their small size, play a decisive role in shaping cellular fate and maintaining biological balance. These unique proteins, built using the rare amino acid selenocysteine, are essential for protecting cells from damage, regulating metabolism, and guiding critical life-and-death decisions within the body.

A comprehensive new analysis is shining a spotlight on Megalin, a powerful and highly versatile receptor that plays a central role in maintaining cellular balance, organ function, and overall human health. This emerging perspective positions Megalin as a critical regulator in processes ranging from nutrient transport to neuroprotection, offering fresh momentum for innovation in disease management.