Polycystic ovary syndrome (PCOS) represents a significant health concern for women of reproductive age, manifesting as a complex endocrine disorder with diverse clinical presentations. Characterized by hyperandrogenism, ovulatory dysfunction, and polycystic ovarian morphology, PCOS affects 5% to 20% of women and stands as a leading cause of anovulatory infertility. The pathophysiology of PCOS involves abnormal folliculogenesis, resulting in arrested follicular development and the accumulation of small antral follicles. This follicular arrest is accompanied by mitochondrial dysfunction and oxidative stress, contributing to poor oocyte quality and developmental potential. Recent research has highlighted the potential role of neurotensin (NTS), a gut-brain peptide, in the regulation of ovulation and its dysfunction in PCOS.

Atopic dermatitis (AD) is a chronic inflammatory skin disease with high prevalence, especially in children. Current treatments like topical glucocorticoids have limitations due to side effects and resistance. Traditional Chinese medicine (TCM) offers alternative solutions, with Qin-Zhu-Liang-Xue (QZLX) decoction showing efficacy in AD treatment. This study explores the mechanisms of QZLX using network pharmacology and evaluates its clinical effects through trials and animal experiments.

Ovarian cancer, a leading cause of death among gynecological malignancies, has a poor prognosis and low 5-year survival rate, necessitating new therapeutic strategies. CDK4/6 inhibitors show promise but their efficacy varies, highlighting the need for biomarkers. This study explores TRIM4's role in ovarian cancer's response to CDK4/6 inhibitors, revealing that TRIM4, an E3 ligase, influences sensitivity by modulating hnRNPDL and CDKN2C levels.

The mechanism of radiosensitizing effect of Semen podocarpi extract on CNE-2R cells is explored.

GPs can more accurately identify older people’s frailty and intervene earlier as a result of NIHR-funded research led by the University of Leeds. 

Timely follow-up colonoscopies can reduce the mortality rate from colorectal cancer, and patient navigators can play an important role in facilitating screening, according to researchers at the U of A Cancer Center.