New research from Oregon Health & Science University shows that millions of Medicaid-enrolled youth are now covered by managed care organizations owned by one of five national parent firms, and that behavioral health care patterns differ meaningfully depending on which firm a child’s plan belongs to.

Tissue-resident immune cells in the lungs can be dysfunctional and cause inflammation. Patients with autoimmune diseases such as lupus, rheumatoid arthritis, or scleroderma often have chronic lung inflammation.

UCLA researchers have identified a promising strategy to make a new class of targeted cancer therapies more effective against one of the deadliest forms of prostate cancer, potentially overcoming treatment resistance that has limited their success.

McGill University researchers have developed a new tool to identify heart disease risk in women earlier in life.

Findings from a study published in JACC: Advances highlight gaps in existing approaches.

“Heart disease is the leading cause of death in women, yet existing risk tools were developed in older populations and ignore factors unique to women,” said senior author Robert Platt, Professor in the Department of Epidemiology, Biostatistics, and Occupational Health and Director of the School of Population and Global Health.

While pregnancy complications are known to be linked to future heart risk, there has been no way to identify which younger women are most at risk, he added.

Researchers have demonstrated a way to drastically reduce the computing power needed to run large-scale optimization models while still producing near-optimal results.

About the Study: This randomized clinical trial examines 1-year safety and efficacy outcomes in patients who underwent intra-arterial thrombectomy or medical management following an acute ischemic stroke with large-core infarcts.

About the Study: Does the addition of high-dose vitamin D to standard treatment improve progression-free survival in patients with metastatic colorectal cancer? In this multicenter, double-blind phase 3 randomized clinical trial in patients with previously untreated metastatic colorectal cancer, the addition of high-dose vitamin D to standard treatment did not significantly improve progression-free survival compared with standard-dose vitamin D (median progression-free survival, 11.8 months vs 10.3 months, respectively). High-dose vitamin D did not improve progression-free survival in patients with metastatic colorectal cancer.

About the Study: Can automated analysis of 1 to 2 minutes of connected speech yield interpretable profiles that distinguish primary progressive aphasia (PPA) variants and reflect neuroanatomical and neuropathologic substrates? In this cross-sectional study of 214 participants, Lasso multinomial modeling generated variant-specific speech profile scores that differentiated nonfluent PPA, logopenic PPA, and semantic PPA with high overall performance and showed expected atrophy associations. In an autopsy-confirmed subset, speech profiles also discriminated common neuropathologic classes. Results suggest that brief automated speech profiling may enable scalable, interpretable support for PPA differential diagnosis and monitoring.