Most patients with Alzheimer's disease and Alzheimer's Disease Related Dementias (ADRD) experience the gradual onset and progression of cognitive symptoms, leading to decline over years or decades. However, in a small subset of patients, symptoms begin rapidly, leading to dementia within one year and complete incapacitation within two years of symptom onset. A new study at Mayo Clinic aims to determine why patients with Alzheimer’s disease and ADRD develop this rapidly progressive dementia (RPD).

In a new report, researchers document trends in shooting victimizations in Lansing, MI, before and after implementation of a program geared toward reducing cyclical and retaliatory gun violence and promoting community healing. Overall, shootings in Lansing fell after the implementation of the project, with some variations between years and communities.

Misled by patients' weight, other factors, providers may miss opportunities for treatment.

The drug tirzepatide improved kidney function and cardiovascular outcomes among patients with obesity and heart failure with preserved ejection fraction (HFpEF) compared with placebo at one year, according to featured clinical research presented at the American College of Cardiology’s Annual Scientific Session (ACC.25) and simultaneously published in JACC. The overall rate of cardiovascular death or worsening heart failure, the trial’s primary endpoint, was higher in the 60% of study participants who also had chronic kidney disease. However, tirzepatide reduced the risk of the primary endpoint to a similar degree in patients with and without kidney disease.