In a paper published in Science Bulletin, the research team led by Professor Wen Zhang from the Department of Rheumatology and Immunology at Peking Union Medical College Hospital (PUMCH) has made significant progress in understanding the pathogenesis of IgG4-related disease (IgG4-RD). The study, for the first time, demonstrates that the overexpression of early growth response factor-1 (EGR1) in epithelial cells is a core driver promoting the characteristic tissue fibrosis of the disease, laying a scientific foundation for developing potential targeted therapies.

A team from The University of Osaka found that the intestinal flora works together with the OTUD3 and STING genes to aggravate ulcerative colitis, a disease with no cure that causes major intestinal pain and bloody diarrhea. When the OTUD3 gene is mutated, microbes in the intestinal flora trigger STING signalingOTUD, leading to inflammation in the colon. The intestinal flora and STING signaling may be important new targets for ulcerative colitis treatment.

New research from Emory University reveals that even seemingly small lifestyle improvements decreased one’s risk of developing heart disease, and these decreases also translate to lower risk of subsequent conditions, such as cancer, dementia, type 2 diabetes, and eye, liver, and kidney diseases. The study also links heart health to vision, hearing, and dental health. The study analyzed more than 450 peer-reviewed studies, assessing the overall impact of implementing the American Heart Association’s Life’s Simple 7™ metrics, a series of preventative measures, which include: not smoking, healthy eating, regular physical activity, maintaining a healthy weight, and managing blood pressure, cholesterol, and blood sugar.  Even a 1-point improvement on Life’s Simple 7™ scale, which ranges from 0-14 points, translates to critical health gains for the heart and other organs.