Gut microbes help convert low-protein diets into fat-burning metabolic state
Peer-Reviewed Publication
Updates every hour. Last Updated: 24-Jun-2026 07:16 ET (24-Jun-2026 11:16 GMT/UTC)
Interactions between diet and the gut microbiome have been shown to have broad roles in shaping host metabolism and health. Now, researchers at the Human Biology Microbiome Quantum Research Center (WPI-Bio2Q, directed by Kenya Honda, M.D., Ph.D., co-senior author of the study) and Keio University, together with researchers from City of Hope and the Broad Institute, show how specific gut microbes are able to interpret diet and subsequently drive the conversion of white adipose tissue into beige fat, a metabolically active form of fat that burns energy instead of storing it.
The study, which has been published in Nature, also identified the molecular pathways that connect these aspects of dietary protein intake, microbial metabolism, and the host’s fat-burning response.
“These findings show, in a mechanistic way, how gut microbes are able to act as an important mediator of dietary cues, and how these bacteria are able to produce signals that shape host metabolism” said Scott Behie, member of WPI-Bio2Q and co-author of the study.
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