This systematic review comprehensively summarizes treatment approaches for all types of age-related macular degeneration (AMD), including recently approved pharmaceuticals and therapeutic strategies, while providing a detailed overview of ongoing clinical trial developments - offering novel perspectives for AMD prevention and treatment.

A nationwide study published in eGastroenterology reveals that while age-standardised mortality from digestive system malignancies (DSMTs) has declined in China between 2004 and 2021, significant disparities persist by cancer type, gender, and region. Oesophageal, gastric, and liver cancer rates decreased, reflecting effective public health interventions. In contrast, mortality from pancreatic and colorectal cancers rose, especially in males and rural populations. The study also highlights improvements in life expectancy and reductions in premature mortality from DSMTs. However, persistent inequities underline the need for targeted cancer prevention, improved screening, and equitable healthcare access.

When fermented with plant-derived bacteria, stevia leaf extract is toxic to pancreatic cancer cells but not to healthy kidney cells

Modern methods of radiotherapy would fight cancer more effectively and safely if treatments could be planned taking into account the radiation quality of the therapeutic proton beams. An achievement by physicists from the Institute of Nuclear Physics of the Polish Academy of Sciences in Cracow brings us closer to this goal.

Since the start of the SARS-CoV-2 pandemic, several variants of the virus have developed into Variants of Concern (VOCs), as classified by the World Health Organization (WHO). VOCs are virus variants that are predicted or known to cause large waves of infections due to their altered phenotypic characteristics and with risk of altering disease severity, reducing vaccine effectiveness or otherwise leading to increased burden of health care systems. The CoVerage web platform for genomic surveillance of the SARS-CoV-2 virus enables a rapid, computational identification and characterization of potential Variants of Interest (pVOIs), with a lead time of almost three months before their WHO designation as a VOC or as related variant categories and predicts their ability to escape existing immunity acquired by prior vaccinations or infections. Researchers led by Alice McHardy have successfully demonstrated this in a comprehensive analysis published in Nature Communications. Early detection of VOCs is particularly important for vaccine development in order to ensure vaccine protection against new virus variants.

Pain is an important physiological response triggered by physical injury or psychological stressors. While studies have shown that mice housed with mice experiencing pain show heightened pain sensitivity, underlying mechanisms remain unclear. A new study by researchers from Tokyo University of Science finds that exposure to stress calls emitted by mice experiencing pain triggers pain and inflammation in naïve mice, thus providing novel insights into pain perception and its social transmission.