Poly adenosine diphosphate-ribose polymerase (PARP) inhibitors, a class of targeted anticancer therapies, prevent genetic repair mechanisms in cancer cells by competitively binding to the active site of PARP and limiting its activity. A new review study by researchers from Sichuan University, China, outlines the molecular mechanisms of PARP inhibitors and the potential for combination therapies comprising PARP inhibitors and other anticancer drugs to improve treatment outcomes against various cancers while limiting the adverse effects.

A review in Brain Medicine unveils the potential of targeted alpha particle therapy (TAT) as an innovative and exciting breakthrough for neuroendocrine tumours (NETs). Unlike traditional beta-particle treatments, TAT delivers high-energy alpha particles to devastate tumour DNA with precision, offering hope for patients with resistant cancers. Published on 4 March 2025, this study highlights preclinical successes and clinical breakthroughs, positioning TAT as a game-changer in oncology amidst ongoing challenges.

Groundbreaking research shows human brains contain approximately a spoon's worth of microplastics, with dementia patients showing 3-5 times higher concentrations. The findings, highlighted in a new Brain Medicine Commentary, reveal concerning trends in brain tissue contamination and potential links to neurological disorders.

Dr. Melissa Perreault, neuroscientist and professor at the University of Guelph, is breaking new ground by integrating Indigenous perspectives into neuroscience. In a Genomic Press Interview, she shares her personal and professional journey, exploring how her research on neuropsychiatric biomarkers, psychedelic medicine, and neuroethics can drive personalized treatments and create a more inclusive scientific future.

Dr. Nicholas Fabiano, University of Ottawa, is reshaping our understanding of mental health treatment through innovative research on exercise and depression. His personal journey following a broken bone from arm wrestling has led to pioneering work in lifestyle psychiatry, including meta-analyses on exercise's impact on suicide risk and practical frameworks for exercise prescription in psychiatric care.