Hidden genetic mismatch, which triples the risk of a life-threatening immune attack after cord blood transplantation
Peer-Reviewed Publication
Updates every hour. Last Updated: 22-Jun-2026 14:16 ET (22-Jun-2026 18:16 GMT/UTC)
A Japanese study of more than 7,400 patients has identified a genetic mismatch that sharply increases the risk of severe acute graft-versus-host disease (GVHD) following umbilical cord blood transplantation. The specific donor–recipient human leukocyte antigen mismatch triples the likelihood of life-threatening immune complications, and severe acute GVHD itself is associated with significantly worse survival. These findings may help refine donor selection and improve the safety and long-term outcomes of stem cell transplantation.
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