Medicine & Health
Updates every hour. Last Updated: 10-Oct-2025 00:11 ET (10-Oct-2025 04:11 GMT/UTC)
Neopred: A dual-phase CT AI tool for preoperative prediction of pathological response in NSCLC
National Center for Respiratory MedicinePeer-Reviewed Publication
In May 2025, the Journal for ImmunoTherapy of Cancer published a pioneering study entitled “NeoPred: dual-phase CT AI forecasts pathologic response to neoadjuvant chemo-immunotherapy in NSCLC”, led by Professor Jianxing He’s team from the First Affiliated Hospital of Guangzhou Medical University / National Center for Respiratory Medicine.
The study introduces NeoPred, a multimodal artificial intelligence model that combines dual-phase CT scans (pre-treatment and pre-surgery) and clinical features to predict major pathological response (MPR) before surgery in patients undergoing neoadjuvant chemo-immunotherapy for non-small cell lung cancer (NSCLC).
Corresponding Authors: Prof. Jianxing He, Dr. Hengrui Liang Co-First Authors: Dr. Jianqi Zheng, Mr. Zeping Yan, Mr. Runchen Wang Collaborating Institutions: Shanghai Chest Hospital, Liaoning Cancer Hospital, First Affiliated Hospital of Xi’an Jiaotong University
- Journal
- Journal for ImmunoTherapy of Cancer
How state bans increase costs and delay abortion care
University of California - San FranciscoPeer-Reviewed Publication
- Journal
- American Journal of Public Health
- Funder
- Hewlett Foundation
USC researchers define brain scan marker to better classify Alzheimer’s disease-related changes
Keck School of Medicine of USCPeer-Reviewed Publication
USC researchers have identified a new brain imaging benchmark that may improve how researchers classify biologically meaningful changes associated with Alzheimer’s disease, especially in Hispanic and non-Hispanic white populations. Using an advanced brain imaging scan called tau PET, the research team studied over 675 older adults from the Health and Aging Brain Study–Health Disparities (HABS-HD) aiming to identify the optimal brain signal that distinguishes individuals with clinically-relevant biological markers of AD from those who are aging normally. They compared tau PET scans of study participants who were cognitively impaired with those who were not impaired based on cognitive tests to establish a tau cut-point that would indicate a higher risk for Alzheimer’s disease. The team used a new imaging tracer called 18F-PI-2620, to measure tau protein buildup in the brain. They found that when tau levels in the medial temporal lobe—a region deep in the brain—exceeded a certain threshold, it strongly indicated cognitive impairment related to AD. But the tau cut-point was only effective when another abnormal protein, amyloid, was also present in those with cognitive impairment, and it only worked for Hispanic and non-Hispanic White participants. In non-Hispanic Black participants, the tau cut-point did not perform as expected. This suggests that other pathologies or conditions may be driving cognitive decline in this group. The findings reflect a growing focus in AD research on making sure diagnostic tools work for everyone—not just in narrow clinical trial populations.
- Journal
- Imaging Neuroscience
- Funder
- NIH/National Institute on Aging, NIH Office of the Director
New ASU research hunts down drug-resistant microbes
Arizona State UniversityPeer-Reviewed Publication
In a first-of-its-kind pilot project, researchers from the Food and Agriculture Organization of the United Nations, Indonesia’s Ministry of Agriculture and Arizona State University tested the novel integration of a handheld DNA sequencing device within Indonesia’s national antibiotic resistance surveillance system across six chicken slaughterhouses in the Greater Jakarta area. They collected samples from both wastewater and surrounding rivers.
The goal: to determine whether portable DNA sequencing could improve national efforts to track drug-resistant E. coli, a key indicator of antibiotic resistance.
- Journal
- Antibiotics
Beyond the big leagues: Concussion care in community sports
University of South AustraliaPeer-Reviewed Publication
As sport-related concussions continue to spark global concern, researchers at the University of South Australia (UniSA) are turning their attention to a largely overlooked group – non-professional athletes – calling for more rigorous return-to-play assessments to protect everyday players.
- Journal
- Exercise and Sport Sciences Reviews
Study reveals mechanisms behind common mutation and prostate cancer
Michigan Medicine - University of MichiganPeer-Reviewed Publication
A new study from the University of Michigan Rogel Health Cancer Center, published in Science, sheds light on how two distinct classes of mutations in the FOXA1 gene—commonly altered in prostate cancer—drive tumor initiation formation and therapeutic resistance.
- Journal
- Science
- Funder
- NIH/National Cancer Institute, Michigan Prostate SPORE Career Enhancement Program award, NIH/National Cancer Institute, Rogel Fellowship, Prostate Cancer Foundation Young Investigator Award, V Scholar Award