As environmental pollutants pose a serious threat to socioeconomic and environmental health, the development of simple, efficient, accurate and cost-effective methods for pollution monitoring and control remains a major challenge, but it is an unavoidable issue. In the past decade, the artificial nanozymes have been widely used for environmental pollutant monitoring and control, because of their low cost, high stability, easy mass production, etc. However, the conventional nanozyme technology faces significant challenges in terms of difficulty in regulating the exposed crystal surface, complex composition, low catalytic activity, etc. In contrast, the emerging single-atom nanozymes (SANs) have attracted much attention in the field of environmental monitoring and control, due to their multiple advantages of atomically dispersed active sites, high atom utilization efficiency, tunable coordination environment, etc. To date, the insufficient efforts have been made to comprehensively characterize the applications of SANs in the monitoring and control of environmental pollutants. Building on the recent advances in the field, this review systematically summarizes the main synthesis methods of SANs and highlights their advances in the monitoring and control of environmental pollutants. Finally, we critically evaluate the limitations and challenges of SANs, and provide the insights into their future prospects for the monitoring and control of environmental pollutants.

With more than three-quarters of children and teens experiencing depression or anxiety, parents are desperate for effective solutions. Now, new research from the University of South Australia shows that something as simple as regular exercise could be a powerful intervention to support young people’s mental health.

Findings from the largest study of its kind, led by University of Warwick and University Hospitals Coventry and Warwickshire (UHCW) NHS Trust with funding from pregnancy charity Tommy’s, have revealed an abnormal process in the womb lining as the explanation behind some preventable pregnancy loss that paves the way for new treatments for some women who experience recurrent miscarriage.

Researchers explore how 6-PPD quinone (6-PPDQ), an environmental contaminant derived from tire antioxidant N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD), affects the citric acid cycle in C. elegans at environmentally relevant concentrations. The research reveals significant reduction in the citric acid cycle intermediates and key enzyme gene expressions by 6-PPDQ exposure, highlighting the its potential exposure risk on citric acid cycle metabolism.

Objectives: This systematic review aimed to assess the properties and feasibility of existing risk pre diction models for post-intensive care syndrome outcomes in adult survivors of critical illness. Methods: As of November 1, 2023, Cochrane Library, PubMed, Embase, CINAHL, Web of Science, PsycInfo, China National Knowledge Infrastructure (CNKI), SinoMed, Wanfang database, and China Science and Technology Journal Database (VIP) were searched. Following the literature screening process, we extracted data encompassing participant sources, post-intensive care syndrome (PICS) outcomes, sample sizes, missing data, predictive factors, model development methodologies, and metrics for model per formance and evaluation. We conducted a review and classification of the PICS domains and predictive factors identified in each study. The Prediction Model Risk of Bias Assessment Tool was employed to assess the quality and applicability of the studies. Results: This systematic review included a total of 16 studies, comprising two cognitive impairment studies, four psychological impairment studies, eight physiological impairment studies, and two studies on all three domains. The discriminative ability of prediction models measured by area under the receiver operating characteristic curve was 0.68e0.90. The predictive performance of most models was excellent, but most models were biased and overfitted. All predictive factors tend to encompass age, pre ICU functional impairment, in-ICU experiences, and early-onset new symptoms. Conclusions: This review identified 16 prediction models and the predictive factors for PICS. Nonetheless, due to the numerous methodological and reporting shortcomings identified in the studies under review, clinicians should exercise caution when interpreting the predictions made by these models. To avert the development of PICS, it is imperative for clinicians to closely monitor prognostic factors, including the in ICU experience and early-onset new symptoms.

Researchers from the Chinese Academy of Sciences and Capital Medical University performed an integrated multi-omics study to compare the effects of acute versus long-term exercise in healthy men. Acute exercise led to temporary responses, while repeated exercise caused adaptive changes, particularly reducing cellular senescence and inflammation and boosting betaine metabolism. The increase in betaine due to exercise, partly through renal biosynthesis, has anti-aging effects and improves age-related health decline in mice. Betaine binds to and inhibits TANK-binding kinase 1 (TBK1), slowing the aging process. These results provide a comprehensive understanding of the molecular benefits of exercise and identify betaine as a potential exercise mimetic for promoting healthy aging.