A recent review highlights the critical role of glutathione S-transferases (GSTs) in human health, emphasizing their influence on disease development, drug metabolism, and therapeutic interventions. These enzymes are responsible for detoxifying harmful compounds, but their dysregulation is linked to severe conditions, including cancer, neurodegenerative disorders, and chronic inflammatory diseases. Genetic variations in GSTs can lead to oxidative stress, DNA damage, and resistance to apoptosis, making them key players in disease pathogenesis.

Hepatocellular carcinoma (HCC), the most common form of liver cancer, continues to pose a significant global health challenge due to its high mortality rate and limited treatment options. However, a new frontier in cancer therapy has emerged, focusing on neddylation modification, a crucial cellular process that influences cancer progression. The latest insights into this mechanism provide hope for targeted therapies that could revolutionize the treatment landscape for HCC.