This review elucidates the central role of metabolic reprogramming in renal fibrosis associated with IgG4-related disease (IgG4-RD), highlighting key pathways such as mitochondrial dysfunction, enhanced glycolysis, and impaired fatty acid oxidation. The study emphasizes the potential of targeting metabolic nodes for antifibrotic therapy and discusses the promise of metabolomics in precision medicine.

A groundbreaking study jointly led by the School of Clinical Medicine at the LKS Faculty of Medicine, of the University of Hong Kong (HKUMed), has found that surgical removal of the diseased parathyroid gland—known as parathyroidectomy—significantly reduces the risk of developing diabetes by 30% in patients with primary hyperparathyroidism (PHPT). The findings add to growing evidence that surgery could provide broader metabolic benefits beyond its known effects on calcium regulation. The study was published in JAMA Surgery.

A research team in the Department of Pharmacology and Pharmacy at the LKS Faculty of Medicine of the University of Hong Kong (HKUMed), has conducted a pioneering study that found an association between walking speed and cancer risk. The researchers found that individuals who walk faster have a markedly lower overall risk of developing cancer, particularly lung cancer. This association was consistent regardless of whether walking speed was self-reported or objectively measured.

A research team from the Department of Pathology at the University of Hong Kong’s LKS Faculty of Medicine (HKUMed) has made a major breakthrough by discovering that atorvastatin, a widely used cholesterol-lowering drug could become a powerful new weapon in the fight against liver cancer. The findings demonstrate how this safe, affordable medication can exploit a hidden weakness in liver cancer cells and boosting the effectiveness of current treatments. This research was published on the Journal of Hepatology.

An Australian research team has achieved an advanced materials breakthrough that opens the door to a new generation of nanodrug applications. From drug delivery, to diagnostics, to gene editing and beyond, the breakthrough has the potential to improve outcomes for patients around the world in coming decades.

A new review study has revealed that per- and polyfluoroalkyl substances (PFAS), widely known as “forever chemicals,” are increasingly entering farmland soils through waste recycling and wastewater reuse. Once in the soil, PFAS can migrate into crops, raising urgent concerns for food safety and human health.