New research on older Floridians reveals a striking disparity in melanoma outcomes. Men experience roughly twice as many melanoma-related deaths as women. Non-Hispanic and white populations also face higher rates of melanoma diagnosis and death than Hispanic groups. Researchers suggest differences likely reflect a combination of higher UV exposure, lower sun-protective behaviors and screening in men, disparities in access to care, and possible biological sex differences in immune response. The findings underscore an uneven burden and urgent need for targeted prevention and early detection.

Institut Pasteur is launching ACT-CHIK (Accelerating Clinical Trials for CHIKungunya Vaccine in Africa), a major four-year research project funded by the Global Health EDCTP3 Joint Undertaking under the European Union's Horizon Europe program. With €15.3 million in EU funding, ACT-CHIK will advance the clinical development of MV-CHIK — a measles-virus-based chikungunya vaccine originally developed at Institut Pasteur — through a large-scale Phase Ib/III clinical trial in four African countries, while preparing for technology transfer to an African vaccine manufacturer.

LRBA deficiency has long been viewed primarily as an immune disorder, but researchers at Science Tokyo have found that the condition may also impair urinary concentrating ability.

Using patient registry data from 43 individuals, mouse models, and protein analysis, the study found that LRBA deficiency can cause excessive urination and electrolyte abnormalities, highlighting the need for closer fluid and sodium monitoring in affected patients.