A new era beyond animal testing: AI-driven framework reinvents chemical risk assessment
Peer-Reviewed Publication
Updates every hour. Last Updated: 23-Dec-2025 04:11 ET (23-Dec-2025 09:11 GMT/UTC)
Why do some children develop a brain that is too small (microcephaly)? An international research team involving the German Primate Center – Leibniz Institute for Primate Research (DPZ), Hannover Medical School (MHH), and the Max Planck Institute of Molecular Cell Biology and Genetics has used human brain organoids to investigate how changes in important structural proteins in the cell lead to this severe developmental disorder (EMBO Reports).
Researchers compared the genomes of two dangerous bacteria, Escherichia coli (E. coli) and Klebsiella pneumoniae, isolated from blood and faecal samples from Tanzanian newborns admitted with fever. In the majority of cases the bacteria were almost genetically identical, suggesting that the same strain had moved from the gastrointestinal tract into the blood. There was also a bacterial strain that acquired an antimicrobial resistance (AMR) gene between the gut and the blood, a concerning development which limits treatment options.
These findings will support future diagnostic strategies since stool samples are far easier to collect from newborns than blood, allowing clinicians to identify infants at risk of developing sepsis. This development would be vital for very low birthweight babies or those in neonatal units where sepsis and AMR outbreaks can be deadly.